. "1064412696"^^ . . . "Smith\u2013Waterman algorithm"@en . . . "1606195"^^ . . . "The Smith\u2013Waterman algorithm performs local sequence alignment; that is, for determining similar regions between two strings of nucleic acid sequences or protein sequences. Instead of looking at the entire sequence, the Smith\u2013Waterman algorithm compares segments of all possible lengths and optimizes the similarity measure."@en . . . . . . . "36313"^^ . . "The Smith\u2013Waterman algorithm performs local sequence alignment; that is, for determining similar regions between two strings of nucleic acid sequences or protein sequences. Instead of looking at the entire sequence, the Smith\u2013Waterman algorithm compares segments of all possible lengths and optimizes the similarity measure. The algorithm was first proposed by Temple F. Smith and Michael S. Waterman in 1981. Like the Needleman\u2013Wunsch algorithm, of which it is a variation, Smith\u2013Waterman is a dynamic programming algorithm. As such, it has the desirable property that it is guaranteed to find the optimal local alignment with respect to the scoring system being used (which includes the substitution matrix and the gap-scoring scheme). The main difference to the Needleman\u2013Wunsch algorithm is that negative scoring matrix cells are set to zero, which renders the (thus positively scoring) local alignments visible. Traceback procedure starts at the highest scoring matrix cell and proceeds until a cell with score zero is encountered, yielding the highest scoring local alignment. Because of its quadratic complexity in time and space, it often cannot be practically applied to large-scale problems and is replaced in favor of less general but computationally more efficient alternatives such as (Gotoh, 1982), (Altschul and Erickson, 1986), and (Myers and Miller, 1988)."@en .