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Statements

Subject Item
dbr:BLAT_(bioinformatics)
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BLAT (bioinformatics)
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BLAT (BLAST-like alignment tool) is a pairwise sequence alignment algorithm that was developed by Jim Kent at the University of California Santa Cruz (UCSC) in the early 2000s to assist in the assembly and annotation of the human genome. It was designed primarily to decrease the time needed to align millions of mouse genomic reads and expressed sequence tags against the human genome sequence. The alignment tools of the time were not capable of performing these operations in a manner that would allow a regular update of the human genome assembly. Compared to pre-existing tools, BLAT was ~500 times faster with performing mRNA/DNA alignments and ~50 times faster with protein/protein alignments.
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BLAT
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dbr:Protein dbr:Sequence_alignment n7:BLAT_Search_Genome.png dbc:Bioinformatics_software dbr:Heuristic_(computer_science) dbr:Intron dbr:Homology_(biology) dbr:Exon dbr:DNA dbr:Nucleotide dbr:BLAST_(biotechnology) dbr:University_of_California,_Santa_Cruz dbr:Amino_acid dbr:Hash_table dbr:Human_genome dbr:Algorithm dbr:RNA_splicing dbr:Expressed_sequence_tag dbr:Messenger_RNA dbr:Dynamic_programming dbc:Laboratory_software dbr:Jim_Kent dbr:List_of_sequence_alignment_software n7:BLAT_indexing.png
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dbo:abstract
BLAT (BLAST-like alignment tool) is a pairwise sequence alignment algorithm that was developed by Jim Kent at the University of California Santa Cruz (UCSC) in the early 2000s to assist in the assembly and annotation of the human genome. It was designed primarily to decrease the time needed to align millions of mouse genomic reads and expressed sequence tags against the human genome sequence. The alignment tools of the time were not capable of performing these operations in a manner that would allow a regular update of the human genome assembly. Compared to pre-existing tools, BLAT was ~500 times faster with performing mRNA/DNA alignments and ~50 times faster with protein/protein alignments.
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